Can I Use a PCIe NVMe SSD in a PCIe Motherboard Slot?

The drives just slot into the slot on the motherboard and are connected via NVMe to the CPU Image Photo of SSD drive

Support 2-DIMM DDR4-1866213324002666 up to 32G maximum capacity; Support 12 x PCIe slots; Support Connector; Support HDMI Connector PDF

m2 vs nvme slot You probably have a 10th gen CPU? In that case, M2_1 is inactive This first slot gets PCIe x4 lanes directly from the CPU,

m2 slot types Motherboard via one of: PCIe ×4; PCIe ×4; PCIe ×4; Serial ATA 2 slots on motherboards and other devices do not support all SSD sizes